For those in their 40s, damage caused by sun exposure becomes apparent. More aggressive skincare can help combat the visible signs of aging. A combination of topical solutions like tretinoin (Retin-A), AHAs and BHAs along with microdermabrasion bring the best results. There are many procedures available to smooth and tighten skin. Fillers like Radiesse, Juvederm, Restylane, and Perlane can help restore volume in the mid-face and fill smile lines. For upper face and forehead lines, Botox or Dysport injections may be in order. For those who choose the surgical route, Mid-face lift, brow-lift and eye lid surgery are very popular procedures.